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CERN detects signal beyond the Standard Model Mars Habitat Alpha: all 6 crew exit healthy after 72-hour test Quantum processor hits room-temperature coherence milestone Solar efficiency record broken — 47.6% under standard conditions Geneva AI Accord signed by 78 nations CRISPR 3.0 achieves 99.3% accuracy in mitochondrial editing CERN detects signal beyond the Standard Model Mars Habitat Alpha: all 6 crew exit healthy after 72-hour test Quantum processor hits room-temperature coherence milestone Solar efficiency record broken — 47.6% under standard conditions Geneva AI Accord signed by 78 nations CRISPR 3.0 achieves 99.3% accuracy in mitochondrial editing

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CRISPR 3.0 Edits Mitochondrial DNA With 99.3% Precision — A Breakthrough Once Thought Impossible

A new base-editing approach from the Broad Institute corrects inherited energy disorders at the source, opening the door to treatments for dozens of previously untreatable conditions.

Dr. S. Park, Biology Correspondent March 6, 2026 6 min read

DNA

Fluorescence microscopy image showing edited mitochondria within a human fibroblast cell line.

For two decades, gene editors have been able to rewrite the DNA inside a cell's nucleus. But the mitochondria have remained stubbornly out of reach — until now. The Broad Institute team achieved correction efficiency of 99.3% with no detectable off-target edits.

"We have been trying to crack this problem for eleven years. When we saw the sequencing results, none of us said anything for about thirty seconds."

— Dr. Soo-Yeon Park, lead author

99.3%

Editing Precision

1:5000

Disease Prevalence

Mitochondrial Genes

CRISPR 3.0 Edits Mitochondrial DNA With 99.3% Precision — A Breakthrough Once Thought Impossible

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